I'd love to see Baron Sengir as a planeswalker, although I think the reprint of Sengir Vamp in 2012 might lean away from the vamp idea for Innistrad a bit. Why hold Nocturnus back for Innistrad, but print an old-school iconic card like Sengir vamp in 2012? Just strikes me as a little odd.
The whole werewolf idea is intriguing (Lycanthropy anyone?), but I swear to god if I see a Sparkling Vampire in Innistrad, I'm punchin' someone lol (j/k about punching someone, but seriously, screw Twilight lol)

Like Bad moon? 😀

Secondly, he's a mythic rare, and one of the few mythics in M12 to not be a reprint (as Inferno titan is confirmed (which basically means so are the rest) and at least two planeswalkers have been confirmed as reprints, with the other three seeming likely). Granted, for a lot of people the walkers are still chase cards, and the titans doubly so, but I'd be kinda shocked if the only chase mythics Wizards printed in M12 were reprints.

Thirdly, there is the fact that he is a tribal leader at mythic. The strong vampire sub-theme in M12 does not validate a tribal leader at mythic by its self, a rare one for sure, but not really a mythic, mythic slots are usually reserved for cards expected to dominate the meta game (granted a few exceptions exist such as time reversal). Without more vamps in standard Blood lord of Vaasgoth will barely see standard play, and definitely not in decks that dominate the format.

Finally, it seems to me like Wizards is trying to make vampires viable in extended play. With 3 core sets in a row featuring vampire lords, two of them at mythic rating and the other a rare, and this 3rd one coming as the zendikar vampires are about to phase out of standard.

OK, now, consider that there is a bit more than just telling a story when it comes to making a block of cards. There is mechanics, and, well, no insult to the folks at Wizards…but there is BUSINESS. And, vampire decks are quite popular in standard right now thanks to Zendikar. But, when Innistrad comes out, a lot of those vampires go “poof”.

So…does that guarantee that vampires will be in Innistrad? No, it doesn’t. In fact, there will be a nice new crop of suck-heads coming in M12 (just check out the plethora of spoiler pages, Sorin has a rather toothy crew coming with him). Now…will Liliana be a vampiress, or a zombie queen? Me, personally, I tend to think of her as more zombiish, as her end game is to reanimate everyone else’s dead and beat them over the head with them. Sounds more like a necromancer than a vampiress.

Do I have a problem with Vampires making a startling resurrection in Standard? Nope. In fact, I am following quite intently, as I have plans for a Standard Sucker Deck myself.

"Horror Lurks Within" could be ironic, and we could get a whole block dedicated to bunnies and rainbows and unicorns. Maybe we need to wait for m12 to make these card speculations. What if they decide to reprint nocturnus in that set?
Also, they usually like to put some cards that will work with the next block in the core set. No one would buy it if they didnt. Thats my 2 cents, im just not sure vampires are whats going to be in innistrad. i could be wrong though.

But since it was in shards here is my guess of more likely mechanics.

Future Sight mechanics that make sense-

Delve
Gravestorm

Other noteworthy mechanics-

Dredge

Transmute- Perhaps a card that can do something in your grave so you would want to transmute it even more. Kind of like an incentive to cycle Viscera Dragger.

Threshold
Flashback
Madness

Perhaps a Delve Threshold contrast to make players think durring draft

Black – Vampires (obviously)
Green – Werewolves
Blue – Liches
Red – Frankenstein monster-inspired creatures
White – Ghosts

here's to hoping

Check out the Day of Judgement flavor text. I think that's what he was referring to.

Didn't Nissa planeswalk to go find Sorin to drag back and help?

Lol